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Serum alkaline phosphatase plays a role in vascular calcification. It is found in various tissues, whereas bone-specific alkaline phosphatase (BAP) more specifically reflects mineral metabolism. The relationship of serum alkaline phosphatase (total and bone-specific) with diabetes and metabolic syndrome (MetS), 2 major risk factors of vascular calcification, is largely unknown.

The Relationship Between Glucose Metabolism, Metabolic Syndrome, and Bone-Specific Alkaline Phosphatase: A Structural Equation Modeling Approach