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Polycystic ovary syndrome (PCOS), the commonest cause of anovulatory infertility, is characterized by disordered follicle development including increased activation and accelerated growth of preantral follicles. Data from experimental animals and preliminary results from studies of human ovarian tissue suggest that IGFs affect preantral follicle development.

Role of Insulin-like Growth Factors in Initiation of Follicle Growth in Normal and Polycystic Human Ovaries