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The onset of labor appears to involve the activation of myometrial inflammatory pathways, and transcription factors such as nuclear factor-κB (NF-κB) control expression of the contraction-associated proteins required to induce a procontractile phenotype. These responses might involve CRH, which integrates immune and neuroendocrine systems.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Corticotropin-Releasing Hormone Interacts With Interleukin-1β to Regulate Prostaglandin H Synthase-2 Expression in Human Myometrium During Pregnancy and Labor