Open AccessHigh Prevalence ofRASMutations inRET-Negative Sporadic Medullary Thyroid Carcinomas
Author(s) -
Margarida M. Moura,
Branca Cavaco,
António E. Pinto,
Valeriano Leite
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2010-1921
Subject(s) - medullary cavity , thyroid carcinoma , medicine , oncology , thyroid , cancer research , pathology , biology
Sporadic medullary thyroid carcinomas (MTC) frequently harbor mutations in the RET protooncogene. We have earlier reported a series of 51 sporadic MTC with 64.7% of RET-positive and 35.3% of RET-negative cases.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom