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The mechanisms relating being born small for gestational age (SGA) and the later risk of metabolic disorders are not yet fully understood. Adipose 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity and expression have been positively associated with metabolic syndrome. In humans, no in vivo studies have explored 11beta-HSD1 activity and gene expression in sc adipose tissue of SGA subjects.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

11β-Hydroxysteroid Dehydrogenase Type 1 of the Subcutaneous Adipose Tissue Is Dysregulated But Not Associated with Metabolic Disorders in Adults Born Small for Gestational Age