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Glucocorticoid resistance due to mutations of the glucocorticoid receptor (NR3C1) are rare, but reduced glucocorticoid sensitivity may play a role in steroid-resistant asthma, inflammatory bowel disease, and septic shock. A rapid and sensitive functional assay to detect glucocorticoid resistance will be advantageous.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Biological and Diurnal Variation in Glucocorticoid Sensitivity Detected with a Sensitive<i>in Vitro</i>Dexamethasone Suppression of Cytokine Production Assay

Biological and Diurnal Variation in Glucocorticoid Sensitivity Detected with a Sensitivein VitroDexamethasone Suppression of Cytokine Production Assay