Open AccessSystematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome
Author(s) -
Guillaume Assié,
Estelle Louiset,
Nathalie Stürm,
Fernande René-Corail,
Lionel Groussin,
Jérôme Bertherat,
Michaël Thomas,
Hervé Lefèbvre,
JeanJacques Feige,
Éric Clauser,
Olivier Chabre,
Nadia Cherradi
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-2281
Subject(s) - g protein coupled receptor , context (archaeology) , cushing syndrome , adrenocorticotropic hormone , receptor , medicine , endocrinology , biology , hormone , paleontology
Stimulation of cortisol secretion through abnormally expressed G protein-coupled receptors (GPCRs) is a frequent feature of ACTH-independent macronodular adrenal hyperplasia (AIMAH). This has opened a pharmacological strategy that targets GPCRs for the treatment of Cushing's syndrome in AIMAH. However, only few drugs are available for the presently described GPCRs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom