A Large Study of Androgen Receptor Germline Variants and Their Relation to Sex Hormone Levels and Prostate Cancer Risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium | Zendy

Sara Lindström | Zendy; Jing Ma | Zendy; David Altshuler | Zendy; Edward L. Giovannucci | Zendy; Elio Ríboli | Zendy; Demetrius Albanes | Zendy; Naomi E. Allen | Zendy; Sonja I. Berndt | Zendy; Heiner Boeing | Zendy; H. Bas Bueno-de-Mesquita | Zendy; Stephen J. Chanock | Zendy; Alison M. Dunning | Zendy; Heather Spencer Feigelson | Zendy; J. Michael Gaziano | Zendy; Christopher A. Haiman | Zendy; Richard B. Hayes | Zendy; Brian E. Henderson | Zendy; David J. Hunter | Zendy; Rudolf Kaaks | Zendy; Laurence N. Kolonel | Zendy; Loı̈c Le Marchand | Zendy; Carmen Martínez | Zendy; Kim Overvad | Zendy; Afshan Siddiq | Zendy; Meir J. Stampfer | Zendy; Pär Stattin | Zendy; Daniel O. Stram | Zendy; Michael J. Thun | Zendy; Dimitrios Trichopoulos | Zendy; Rosario Tumino | Zendy; Jarmo Virtamo | Zendy; Stephanie J. Weinstein | Zendy; Meredith Yeager | Zendy; Peter Kraft | Zendy; Matthew L. Freedman | Zendy

Open Access

A Large Study of Androgen Receptor Germline Variants and Their Relation to Sex Hormone Levels and Prostate Cancer Risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium

Author(s) -

Sara Lindström,

Jing Ma,

David Altshuler,

Edward L. Giovannucci,

Elio Ríboli,

Demetrius Albanes,

Naomi E. Allen,

Sonja I. Berndt,

Heiner Boeing,

H. Bas Bueno-de-Mesquita,

Stephen J. Chanock,

Alison M. Dunning,

Heather Spencer Feigelson,

J. Michael Gaziano,

Christopher A. Haiman,

Richard B. Hayes,

Brian E. Henderson,

David J. Hunter,

Rudolf Kaaks,

Laurence N. Kolonel,

Loı̈c Le Marchand,

Carmen Martínez,

Kim Overvad,

Afshan Siddiq,

Meir J. Stampfer,

Pär Stattin,

Daniel O. Stram,

Michael J. Thun,

Dimitrios Trichopoulos,

Rosario Tumino,

Jarmo Virtamo,

Stephanie J. Weinstein,

Meredith Yeager,

Peter Kraft,

Matthew L. Freedman

Publication year - 2010

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2009-1911

Subject(s) - prostate cancer , oncology , androgen receptor , medicine , breast cancer , cohort , germline , cancer , male breast cancer , gynecology , biology , gene , genetics

Androgens are key regulators of prostate gland maintenance and prostate cancer growth, and androgen deprivation therapy has been the mainstay of treatment for advanced prostate cancer for many years. A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes.

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