Open AccessRuns of Homozygosity Identify a Recessive Locus 12q21.31 for Human Adult Height
Author(s) -
TieLin Yang,
Yan Guo,
Li-Shu Zhang,
Qing Tian,
Han Yan,
Christopher J. Papasian,
Robert R. Recker,
HongWen Deng
Publication year - 2010
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1715
Subject(s) - runs of homozygosity , international hapmap project , genetics , biology , heritability , framingham heart study , locus (genetics) , genome wide association study , quantitative trait locus , genetic variation , allele , single nucleotide polymorphism , genotype , gene , medicine , haplotype , framingham risk score , disease
Runs of homozygosity (ROHs) have recently been proposed to have potential recessive significance for complex traits. Human adult height is a classic complex trait with heritability estimated up to 90%, and recessive loci that contribute to adult height variation have been identified.
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