Open AccessConcomitant Medication Use Can Confound Interpretation of the Combined Dexamethasone-Corticotropin Releasing Hormone Test in Cushing’s Syndrome
Author(s) -
Elena Valassi,
Brooke Swearingen,
Hang Lee,
Lisa B. Nachtigall,
Daniel A. Donoho,
Anne Klibanski,
Beverly M. K. Biller
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1500
Subject(s) - dexamethasone , concomitant , corticotropin releasing hormone , medicine , endocrinology , confidence interval , dexamethasone suppression test , cushing syndrome , hydrocortisone , adrenocorticotropic hormone , hormone
The ability of combined dexamethasone-corticotropin releasing hormone (Dex-CRH) testing to distinguish pseudo-Cushing's syndrome (PCS) from Cushing's syndrome is controversial. One factor potentially impairing diagnostic efficacy is the concomitant use of commonly prescribed medications that may alter dexamethasone metabolism.
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