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Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells commonly caused by an inherited or acquired RET proto-oncogene mutation. Therapeutic resistance and recurrence of the disease imply the presence of cancer stem cells in MTC.

Medullary Thyroid Carcinoma Cell Lines Contain a Self-Renewing CD133+Population that Is Dependent on Ret Proto-Oncogene Activity

Medullary Thyroid Carcinoma Cell Lines Contain a Self-Renewing CD133⁺Population that Is Dependent on Ret Proto-Oncogene Activity