Open AccessProgrammed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison’s Disease and Graves’ Disease Susceptibility
Author(s) -
Anna L. Mitchell,
Heather J. Cordell,
Rachel Soemedi,
Kate Owen,
Beate Skinningsrud,
Anette S. B. Wolff,
Martina Ericksen,
Dag E. Undlien,
Eystein S. Husebye,
Simon H. S. Pearce
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1404
Subject(s) - odds ratio , medicine , single nucleotide polymorphism , cohort , haplotype , genotype , confidence interval , snp , gastroenterology , immunology , genetics , biology , gene
Despite much investigation, a substantial amount of the genetic susceptibility to autoimmune diseases remains unaccounted for. Recently, a single-nucleotide polymorphism (SNP) in the programmed death ligand 1 (PD-L1) gene has been associated with Graves' disease (GD) in a Japanese patient cohort. Our aim was to determine whether variants in PD-L1 are also associated with autoimmune Addison's disease (AAD) and to replicate the previous association in patients with GD from the United Kingdom.
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