Open AccessProgesterone and Mifepristone Regulate L-Type Amino Acid Transporter 2 and 4F2 Heavy Chain Expression in Uterine Leiomyoma Cells
Author(s) -
Xia Luo,
Ping Yin,
Scott Reierstad,
Hiroshi Ishikawa,
Zhihong Lin,
Mary Ellen Pavone,
Hong Zhao,
Erica E. Marsh,
Serdar E. Bulun
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1286
Subject(s) - transporter , biology , leiomyoma , amino acid , transmembrane protein , context (archaeology) , uterine leiomyoma , cloning (programming) , microbiology and biotechnology , gene , endocrinology , receptor , medicine , uterus , biochemistry , pathology , paleontology , programming language , computer science
Progesterone and its receptor (PR) play key roles in uterine leiomyoma growth. Previously, using chromatin immunoprecipitation-based cloning, we uncovered L-type amino acid transporter 2 (LAT2) as a novel PR target gene. LAT2 forms heterodimeric complexes with 4F2 heavy chain (4F2hc), a single transmembrane domain protein essential for LAT2 to exert its function in the plasma membrane. Until now, little is known about the roles of LAT2/4F2hc in the regulation of the growth of human uterine leiomyoma.
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