Open AccessHypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
Author(s) -
David Henley,
Georgina Russell,
J. A. Douthwaite,
Susan A. Wood,
Fiona Buchanan,
Rosemary Gibson,
Wolfram Woltersdorf,
J R Catterall,
Stafford L. Lightman
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1174
Subject(s) - medicine , endocrinology , ultradian rhythm , continuous positive airway pressure , adrenocorticotropic hormone , obstructive sleep apnea , hydrocortisone , pulsatile flow , liter , sleep apnea , hormone , circadian rhythm
Obstructive sleep apnea (OSA) is a common condition with significant cardiovascular and metabolic comorbidity. We hypothesized that these may result from OSA-induced perturbations of endogenous ultradian hypothalamic-pituitary-adrenal axis activity.
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