Open AccessThe Exon-3 Deleted Growth Hormone Receptor Polymorphism Predisposes to Long-Term Complications of Acromegaly
Author(s) -
M. J. E. Wassenaar,
Nienke R. Biermasz,
Alberto M. Pereira,
Agatha A. van der Klaauw,
Johannes W. A. Smit,
Ferdinand Roelfsema,
Tahar van der Straaten,
Marcel Cazemier,
Daniël W. Hommes,
Herman M. Kroon,
M. Kloppenburg,
HenkJan Guchelaar,
Johannes A. Romijn
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2009-1172
Subject(s) - acromegaly , exon , polymorphism (computer science) , growth hormone , medicine , term (time) , receptor , hormone , endocrinology , genetics , biology , genotype , gene , physics , quantum mechanics
The aim of the study was to evaluate the impact of the genomic deletion of exon 3 of the GH receptor (d3GHR) on long-term clinical outcome of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom