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Most children born small for gestational age (SGA) normalize their body size by late infancy. Between 2 and 6 yr, such SGA children develop higher circulating levels of insulin, lower levels of adiponectin, and more visceral fat than appropriate-for-gestational-age (AGA) controls, even in the absence of overweight. Here we report on their further course between 6 and 8 yr. STUDY DESIGN AND POPULATION: Longitudinal study over 2 yr comparing data from 32 AGA vs. 32 SGA children, matched for gender, height, weight, and body mass index at the age of 6 yr.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Low-Birth Weight Children Develop Lower Sex Hormone Binding Globulin and Higher Dehydroepiandrosterone Sulfate Levels and Aggravate their Visceral Adiposity and Hypoadiponectinemia between Six and Eight Years of Age