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CXC alpha-chemokine CXCL10/IP-10 plays an important role in the initial phases of Graves' ophthalmopathy (GO). Human thyrocytes, orbital fibroblasts, and preadipocytes are stimulated to produce CXCL10 when treated with interferon gamma (IFNgamma) and TNFalpha. Peroxisome proliferator-activated receptor-gamma (PPARgamma) activation plays an inhibitory role in this process.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Monokine Induced by Interferon γ (IFNγ) (CXCL9) and IFNγ Inducible T-Cell α-Chemoattractant (CXCL11) Involvement in Graves’ Disease and Ophthalmopathy: Modulation by Peroxisome Proliferator-Activated Receptor-γ Agonists