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Increased myometrial sensitivity to oxytocin at term is mediated through increased oxytocin receptor (OTR) expression. OTR promoter contains putative transcription factor-binding sites for activating protein-1 (AP-1), CCAAT/enhancer-binding protein (C/EBP), and nuclear factor-kappaB (NF-kappaB), which may be activated by IL-1beta, whose concentrations increase with labor.

Regulation of the Human Oxytocin Receptor by Nuclear Factor-κB and CCAAT/Enhancer-Binding Protein-β