Open AccessGlucocorticoid Receptor Polymorphism Affects Transrepression But Not Transactivation
Author(s) -
Erica L. T. van den Akker,
Henk Russcher,
Elisabeth F. C. van Rossum,
Albert O. Brinkmann,
Frank H. de Jong,
Anita Hokken,
Huibert A. P. Pols,
Jan W. Koper,
Steven W. J. Lamberts
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-2119
Subject(s) - transrepression , transactivation , glucocorticoid receptor , glucocorticoid , endocrinology , medicine , context (archaeology) , proinflammatory cytokine , receptor , biology , gene , gene expression , genetics , inflammation , paleontology
Glucocorticoids (GCs) are extensively used in the treatment of inflammatory and autoimmune diseases. Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom