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Endometriosis, the growth of endometrial tissue outside the uterus, is principally an estrogen-dependent disease. In contrast, exposure to progesterone during pregnancy or therapeutically has been shown to provide benefit to some women with this disease. However, recent research suggests that the presence of endometriosis impairs the capacity of the eutopic endometrium to respond to endogenous progesterone.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Down-Regulation of Endometrial Matrix Metalloproteinase-3 and -7 Expression<i>in Vitro</i>and Therapeutic Regression of Experimental Endometriosis<i>in Vivo</i>by a Novel Nonsteroidal Progesterone Receptor Agonist, Tanaproget

Down-Regulation of Endometrial Matrix Metalloproteinase-3 and -7 Expressionin Vitroand Therapeutic Regression of Experimental Endometriosisin Vivoby a Novel Nonsteroidal Progesterone Receptor Agonist, Tanaproget