Open AccessAssociation of Cryptorchidism with a Specific Haplotype of the Estrogen Receptor α Gene: Implication for the Susceptibility to Estrogenic Environmental Endocrine Disruptors
Author(s) -
Rie Yoshida,
Maki Fukami,
Isoji Sasagawa,
Tomonobu Hasegawa,
Naoyuki Kamatani,
Tsutomu Ogata
Publication year - 2005
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-0211
Subject(s) - haplotype , single nucleotide polymorphism , context (archaeology) , biology , estrogen receptor , genotyping , estrogen receptor alpha , genetics , case control study , estrogen , endocrine system , medicine , genotype , endocrinology , gene , breast cancer , hormone , cancer , paleontology
The prevalence of cryptorchidism (CO) has increased during the past few decades in several countries, and this event has primarily been ascribed to the estrogenic effects of environmental endocrine disruptors (EEDs). Little is known, however, about the role of genetic susceptibility to EEDs in this phenomenon.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom