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Cytokines and insulin-like growth factors (IGFs) are involved in the induction and/or perpetuation of inflammatory bowel disease. The effect of fasting on inflammatory bowel disease was studied in a mouse experimental model of acute colitis caused by adding dextran sulfate sodium (DSS) to drinking water. Animals were either fed ad libitum or fasted (water only) for 2 days before death. Inflammation and tissue damage, measured as a colitis activity score, were markedly reduced in fasted (2.4 +/- 0.1) compared to fed (5.3 +/- 0.1) DSS animals (P &lt; 0.0001). Colon interleukin-1 beta (IL-1 beta), IGF-I, and tumor necrosis factor-alpha messenger RNAs (mRNAs) were quantified by Northern blot hybridization and expressed as a percentage of mRNA abundance in fed controls. In DSS mice, IL-1 beta mRNA was elevated in the fed group (954 +/- 155%; P &lt; 0.001), but was suppressed in fasted animals (71.1 +/- 11%). IGF-I mRNA also was elevated in fed DSS mice (421 +/- 71%; P &lt; 0.01). This increase was attenuated in fasted DSS mice (202 +/- 17%; P &lt; 0.01 compared to fed DSS mice). Tumor necrosis factor-alpha mRNA was increased in fed DSS mice (162 +/- 15%; P &lt; 0.01), but was not significantly lower in fasted animals. By in situ hybridization, IL-1 beta mRNA was localized to the lamina propria of colonic mucosa in fed DSS animals, but was not detectable in other groups. We conclude that fasting has a protective effect on the progression of acute DSS, induced colitis. This is associated with decreased expression of IL-1 beta and IGF-I mRNAs in the colon.

endocrinology

Fasting Prevents Experimental Murine Colitis Produced by Dextran Sulfate Sodium and Decreases Interleukin-1β and Insulin-Like Growth Factor I Messenger Ribonucleic Acid<sup>1</sup>

Fasting Prevents Experimental Murine Colitis Produced by Dextran Sulfate Sodium and Decreases Interleukin-1β and Insulin-Like Growth Factor I Messenger Ribonucleic Acid1

Fasting Prevents Experimental Murine Colitis Produced by Dextran Sulfate Sodium and Decreases Interleukin-1β and Insulin-Like Growth Factor I Messenger Ribonucleic Acid¹