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In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. The aim of the first experiment was to assess whether photoperiodic changes in hypothalamic dopaminergic activity were temporally linked to changes in either PRL or LH secretion. The purpose of the second experiment was to determine whether melatonin mimicked the effects of photoperiod on ME dopaminergic activity. In the first experiment, LH and PRL secretion, hypothalamic tyrosine hydroxylase (TH) activity, and catecholamine contents were determined in ovariectomized estradiol-treated ewes either during long days (LD; control group) or after 5, 25, and 76 short days (SD). SD were associated with a stimulation of LH secretion and a decrease in ME TH activity, which were both expressed only in the 76 SD group. In contrast, the SD-induced inhibition of PRL secretion was already maximal in the 25 SD group. In the second experiment, LH secretion and hypothalamic dopaminergic activity were studied in ovariectomized estradiol-treated ewes kept in LD and then treated for 0 (control), 25, or 77 days with melatonin implants producing a SD-like effect on LH secretion. Melatonin induced a decrease in PRL secretion (observed after 25 days of treatment), as well as a stimulation of LH secretion and a decrease in ME TH activity and dopamine content (observed only after 77 days of treatment). In conclusion, the decrease in ME dopaminergic activity associated with SD exposure or the SD-like effect of melatonin appears unrelated to the regulation of PRL secretion. The SD-like effect of melatonin on ME dopaminergic activity suggests that melatonin mediates the effect of SD on this activity. The regulation of ME dopaminergic activity can thus be considered a probable step in the photoperiodic regulation of LH secretion.

endocrinology

Characterization of the Short Day-Induced Decrease in Median Eminence Tyrosine Hydroxylase Activity in the Ewe: Temporal Relationship to the Changes in Luteinizing Hormone and Prolactin Secretion and Short Day-Like Effect of Melatonin<sup>1</sup>

Characterization of the Short Day-Induced Decrease in Median Eminence Tyrosine Hydroxylase Activity in the Ewe: Temporal Relationship to the Changes in Luteinizing Hormone and Prolactin Secretion and Short Day-Like Effect of Melatonin1

Characterization of the Short Day-Induced Decrease in Median Eminence Tyrosine Hydroxylase Activity in the Ewe: Temporal Relationship to the Changes in Luteinizing Hormone and Prolactin Secretion and Short Day-Like Effect of Melatonin¹