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The nature of and neural mechanisms involved in GH and insulin responses to obesity-inducing ventromedial hypothalamic (VMH) lesions, which infringed on the arcuate nucleus, were examined in freely moving chronically cannulated male rats. Sequential 6-h GH and 3-h insulin and glucose secretory profiles were obtained in VMH-lesioned and sham-operated control rats. Obese VMH rats exhibited hyperinsulinemia with marked fluctuations in plasma insulin levels in the presence of normoglycemia. A striking suppression in both amplitude and duration of GH secretory episodes was observed, with GH peak amplitudes rarely exceeding 90 ng/ml compared to 500 ng/ml in sham-operated controls (mean 6-h plasma GH level, 17.6 ± 6.0 vs. 154.1 ± 17.8 ng/ml; P < 0.001). The periodicity of the GH rhythm was maintained, but light-dark entrainment of the GH pulses was lost. Passive immunization with a specific antiserum to somatostatin (SRIF) failed to restore the amplitude of the GH peaks or to alter significantly the 6-h GH secre...

endocrinology

Effects of Obesity-Inducing Ventromedial Hypothalamic Lesions on Pulsatile Growth Hormone and Insulin Secretion: Evidence for the Existence of a Growth Hormone-Releasing Factor*