Open AccessThe Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*
Author(s) -
Richard G. Pestell,
Chris Albanese,
Anne T. Reutens,
Jeffrey E. Segall,
Richard J. Lee,
Andrew Arnold
Publication year - 1999
Publication title -
endocrine reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.357
H-Index - 272
eISSN - 1945-7189
pISSN - 0163-769X
DOI - 10.1210/edrv.20.4.0373
Subject(s) - cyclin dependent kinase , cyclin , cell cycle , microbiology and biotechnology , cyclin d1 , biology , cyclin d , cancer research , cyclin a , cell , genetics
I. Introduction II. Regulation of the Cell Cycle G1 Phase A. The cyclins B. The Cdk-inhibitory proteins C. Regulation of transcription by cell cycle-control proteins III. Endocrine Regulation of Cyclin and Cdk-Regulatory Proteins A. Single-transmembrane segment receptors B. Seven-transmembrane receptors C. Steroid hormones D. Intracellular second messengers IV. Cyclins and CKIs in Endocrine Tumors A. Parathyroid adenomas B. Thyroid cancer C. Pituitary tumors D. Adrenal tumors E. Ovarian and testicular cancer F. Mechanisms of oncogenic transformation by cyclin D1 G. CKIs in treatment of endocrine disease V. Transcription Factors Regulating the Cell Cycle VI. Conclusion
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