Cancer and Bone*

I. Introduction II. Normal Calcium and Bone Homeostasis A. Bone remodeling B. Calcium homeostasis C. Defenses against hyper- and hypocalcemia III. Humoral Mechanisms by Which Solid Tumors Affect the Skeleton A. Hypercalcemia B. Oncogenic osteomalacia C. Tumor lysis syndrome IV. Local Mechanisms by Which Tumors Affect the Skeleton A. Clinical manifestations B. Pathophysiology of the metastatic process to bone C. Local tumor syndromes in bone D. Therapy of tumor in bone