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Molecular networks act as the backbone of cellular activities, providing an{excellent} opportunity to understand the developmental changes in an organism.While network data usually constitute only stationary network graphs,constructing multilayer PPI network may provide clues to the particulardevelopmental role at each {stage of life} and may unravel the importance ofthese developmental changes. The developmental biology model of {Caenorhabditiselegans} {analyzed} here provides a ripe platform to understand the patterns ofevolution during life stages of an organism. In the present study, the widelystudied network properties exhibit overall similar statistics for all the PPIlayers. Further, the analysis of the degree-degree correlation and spectralproperties not only reveals crucial differences in each PPI layer but alsoindicates the presence of the varying complexity among them. The PPI layer ofNematode life stage exhibits various network properties different to rest ofthe PPI layers, indicating the specific role of cellular diversity anddevelopmental transitions at this stage. The framework presented here providesa direction to explore and understand developmental changes occurring indifferent life stages of an organism.

A multilayer PPI network analysis of different life stages in C. elegans