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Long chain polyunsaturates (LCP) status during the early neonatal period is associated with a reduced risk of atopic symptoms and later allergies. In this study, we characterized the immune response of low-risk, term, formula-fed infants randomized at &lt;or=14 d of age to standard term formula (Formula) or formula containing LCP (Formula+LCP) for 4 wks. Infants exclusively fed human milk were included for comparison. Peripheral blood was collected at 14 and 42 d of age, and lymphocyte phenotype, proliferation, and cytokine production (IL-2, IL-4, IL-6, IL-10, IL-12, IFN-gamma, TNF-alpha, TGFbeta) were assessed after incubation with beta-lactoglobulin (BLG) and soy protein (SOY). Lymphocyte proliferation did not differ between groups. Compared with human milk-fed infants at 2 wks, formula-fed infants produced more TNF-alpha and IFN-gamma and had more cells expressing ICAM-1 (CD54) after incubation with BLG and SOY (p &lt; 0.05). At 6 wks of age, infants fed Formula+LCP produced more TNF-alpha with SOY (3.2-fold) and IFN-gamma (3.3-fold) with BLG compared with infants fed Formula (p &lt; 0.05). In conclusion, low-risk term infants fed formula before 14 d of age produced more TNF-alpha and IFN-gamma in response to food proteins. Feeding Formula+LCP for 4 wks maintained the higher TNF-alpha and IFN-gamma response to these food proteins.

pediatric research

Feeding a Formula Supplemented With Long Chain Polyunsaturated Fatty Acids Modifies the “Ex Vivo” Cytokine Responses to Food Proteins in Infants at Low Risk for Allergy