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The objective of this study was to investigate if increasing maternal dietary linolenic acid (18:3n-3) content, by decreasing the 18:2n-6 to 18:3n-3 ratio, could increase the docosahexaenoic acid (22:6n-3) content in phospholipids of neuronal cells of rat pups at 2 weeks of age. Sprague-Dawley dams at parturition were fed semipurified diets containing decreasing ratios of 18:2n-6 to 18:3n-3 from 21.6:1 to 1:1. During the first 2 weeks of life, the rat pups received only their dam's milk. The fatty acid composition of the pups stomach contents (dam's milk) and the phospholipids from neuronal cells were identified and quantitated by gas-liquid chromatography. The stomach 22:6n-3 content analyzed from the rat pups at 2 weeks of age was altered by the maternal diet. Fatty acid analysis of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in neuronal cells of the rat pups showed no significant increase in 22:6n-3 content with increasing 18:3n-3 in the maternal diet (p &gt; 0.05). In contrast, the content of 22:6n-3 in phosphatidylinositol (PI) was significantly increased by change in dietary 18:3n-3 intake from a dietary 18:2n-6 to 18:3n-3 ratio of 7.8:1 to 4.4:1. It is concluded that increasing maternal dietary 18:3n-3 by decreasing the 18:2n-6 to 18:3n-3 ratio does not significantly increase the 22:6n-3 content in PC, PE, and PS in neuronal cells of rat pups at 2 weeks of age.

Does Increasing Dietary Linolenic Acid Content Increase the Docosahexaenoic Acid Content of Phospholipids in Neuronal Cells of Neonatal Rats?