English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

To determine the effects of inhaled nitric oxide (NO) on pulmonary hemodynamics and gas exchange in experimental hyaline membrane disease (HMD), we studied 16 premature lambs (0.78 term) in two separate protocols. All animals were treated with exogenous surfactant before mechanical ventilation. In protocol 1, we measured the acute response to brief treatment with inhaled NO (20 ppm, 20 min) after 2 h of mechanical ventilation with fraction of inspired oxygen of 1.00 (n = 5). After 2 h, brief NO treatment lowered pulmonary vascular resistance from 0.26 +/- 0.05 to 0.16 +/- 0.03 mm Hg.(mL/min)-1 (p &lt; 0.01) and improved gas exchange (arterial PO2, 44 +/- 9 mm Hg baseline to 168 +/- 45 mm Hg NO, p &lt; 0.01; arterial PCO2 45 +/- 5 mm Hg baseline to 35 +/- 4 mm Hg NO, p &lt; 0.05). In protocol 2, to determine whether early and continuous treatment with inhaled NO could sustain improvement in gas exchange and pulmonary hemodynamics in severe HMD, we compared the physiologic effects of ventilation with high inspired oxygen concentrations for 3 h with NO (20 ppm, n = 6) and without NO (controls, n = 5). After 3 h, the NO treatment group had sustained reduction in pulmonary vascular resistance (0.10 +/- 0.01 mm Hg.(mL/min)-1 NO versus 0.25 +/- 0.04 mm Hg.(mL/min)-1 control, p &lt; 0.05), increased left pulmonary artery blood flow (204 +/- 24 mL/min NO versus 109 +/- 15 mL/min control, p &lt; 0.05), and increased arterial PO2 (114 +/- 27 mm Hg NO versus 36 +/- 11 mm Hg control, p &lt; 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Inhaled Nitric Oxide Improves Gas Exchange and Lowers Pulmonary Vascular Resistance in Severe Experimental Hyaline Membrane Disease