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Technetium-99m labelled Salbutamol was administered through a tracheostomy to ventilated rabbits by either an MDI (5 puffs,100μg/puff) aided with a spacer (MV15 Aerochamber, Trudell, Canada) (Group1, n=7); or by nebulization (100μig/kg in 3ml Technetium-99m labelled 5% albumin). Nebulization was carried out for 20 min. with a Jet (Hudson, USA) (Group 2, n=11)or Ultrasonic device (Siemens, Sweden) using either a standard (Group 3, n=6) or a small (Group 4, n=7) reservoir. Lung deposition was estimated by gamma counting of the autopsy lung specimens: mean(sd):

pediatric research

109 PULMONARY DEPOSITION OF SALBUTAMOL AEROSOL DELIVERED BY METERED DOSE INHALER (MDI), JET NEBULIZER AND ULTRASONIC NEBULIZER IN MECHANICALLY VENTILATED RABBITS