English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Secretion of soluble cytokine receptors has been suggested as a mechanism of regulating cytokine activity in vivo. In this study, the presence of soluble receptors for tumor necrosis factor-alpha (TNF-alpha) in serum samples from pregnant women and newborn babies was examined by using TNF-alpha receptor-specific immunoassays. Serum from pregnant women contained the 55-kD TNF-alpha receptor p55 [6.4 micrograms/L, interquartile range, i.e. the difference between the 25th and 75th percentile, (IQR) 7.2 micrograms/L], whereas p55 was not detected in control sera from nonpregnant, fertile women. The levels of p55 were also elevated in serum from newborns (3.2 micrograms/L, IQR 0.7 micrograms/L). Furthermore, first-voided urine from newborns contained high levels of p55 (44.6 micrograms/L, IQR 96.6 micrograms/L). The concentration of p55 in the neonatal period was significantly higher than that of children later in childhood (p &lt; 0.05). The concentration of p55 was 7.3 micrograms/L, IQR 13.8 micrograms/L, in urine samples from a group of preschool children (1 mo &lt; age &lt; 5 y) and 6.9 micrograms/L, IQR 2.9 micrograms/L, in urine samples from children in a higher age group (5 y &lt; age &lt; 10 y). The concentration of the 75-kD TNF-alpha receptor in urine did not differ significantly between the different age groups studied. The elevated p55 serum levels of pregnant women and neonates are suggestive of a pregnancy-associated release of soluble receptors. The high concentration of p55 in neonatal urine may reflect a postpartum elimination of soluble receptors shed during pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)

Increased Levels of Soluble Tumor Necrosis Factor-α Receptors in Serum from Pregnant Women and in Serum and Urine Samples from Newborns