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Data in the literature concerning atrial natriuretic factor (ANF) physiology in the fetus and newborn, although limited, suggest significant activity during the perinatal period. To characterize further ANF physiology during this time, we documented immunoreactive ANF (IR-ANF) concentrations in the right and left atria before and immediately after birth as well as in the hearts of immature and adult rats. There was a significant decrease in the concentration of IR-ANF in both right and left atria on the d before birth that persisted for the first 48 h of life [d 20 fetal right 570 (106, 90), left 580 (86, 75); d 21 fetal right 270 (70, 55), left 214 (117, 75); 1 d right 206 (39, 33), left 229 (41, 35); 2-d right 352 (35, 32), left 237 (26, 23) [geometric mean (upper SE, lower SE) in ng ANF/mg protein]. Repletion of ANF stores began in the right atrium on d 2 of life and in the left atrium between d 2 and 5. The highest levels of IR-ANF were observed at d 15 [d 5 right 1439 (53,51), left 1547 (83,79); d 15 right 2034 (90,86), left 1943 (108, 102); adult right 1380 (119, 109), left 963 (118, 105)]. In contrast to normal adult animals, factors mediating the observed change affect both atria equally during the perinatal period. The concentration of IR-ANF in the right and left atrium of the fetal, newborn, and immature animals was equal. These data document significant alterations in intraatrial IR-ANF concentrations in the perinatal period.(ABSTRACT TRUNCATED AT 250 WORDS)

Atrial Natriuretic Factor During the Perinatal Period: Equal Depletion in Both Atria'