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High density lipoproteins, in particullar the HDL2 subfraction is proposed to be a “protective” factor regarding the development of atherosclerosis. The effect of 3 a weeks weight reduction regimen (700 kcal) on HDL subtractions in 68 obese (mean±SD overweight 74±23%) children and adolescents aged 10 to 14 years ( 11.7±1.6 years) was investigated. Fasting plasma HDL-cholesterol was determined after ultracentrtfugation and polyanionprecipitation (LDL) enzymatlcally, afterwards HDL subtraction 2 and 3 were measured by precipitation methods (dextran sulfate and polyethylen glycol). Weight loss during the dietary treatment was 7.2±1.5kg.After weight loss a significant reduction of plasma HDL-C by 12% was found. The decline in HDL-C accounted almost entirely for by the reduction of HDL3 levels, whereas HDL2 concentrations remained constant. The HDL2/HDL3 ratio increased slightly. Based on our results we conclude that the decline in HDL-C in obese undergoing weight reduction does not represent an increased atherosclerotic risk. In contrast, the decreased cholesterol and LDL-C levels and the increased HDL2/HDL3 ratio suggests a lowered risk after weight reduction.

78 EFFECT OF WEIGHT REDUCTION ON HDL SUBFRACTIONS IN OBESE CHILDREN AND ADOLESCENTS