English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Between 1:120 and 1:180 of human newborn T cells proliferate in limiting dilution cultures with allogeneic lymphocytes or with Ia-bearing monocytic stimulator cells. The proliferating responder cells were derived from both the OKT 4+ and OKT 8+ subsets as determined by immunofluorescence and by thymidine uptake. Five to seven days after an exchange blood transfusion there was a slight increase in the percentage of OKT 8+ T lymphocytes in the recipient's blood. Newborn blood also contains a population of non-T cells which proliferate in the absence of allogeneic stimulator cells. In limiting dilution cultures, the frequency of these spontaneously dividing cells was 1:3125 of mononuclear cells. Our results suggest that the newborn T lymphocyte proliferative response to alloantigen is mature by the time of birth and they provide no phenotypic explanation for the previous report of mixed lymphocyte culture-induced suppression by newborn T cells. The predominance of newborn metaphases in 2-way mixed lymphocyte cultures with adult cells (on which the previous report of suppression was based) is not seen if the non-T (stimulator) cells are irradiated. These results suggest that the data previously interpreted as evidence for suppression arose through proliferation of newborn non-T cells.

Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction