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Oxygen-derived free radicals with hydroxyl radical (OH.)-like reactivity are products of the human neutrophil respiratory burst. Such radicals, although dependent on O2-generation arise from complex oxidation reactions that may be independent of an iron-or lactoferrin-catalyzed Haber-Weiss mechanism. Differentiated HL-60 promyelocytic leukemia cells completely deficient in lactoferrin generate oxidizing radicals at a rate greater than that of human neutrophils, indicating lactoferrin-independent pathways for OH. generation. The further heterogeneity of pathways generating OH. activity in neutrophils is indicated by the cell concentration dependence of the reaction, the variability of H2O2 as a precursor reactant, and the various proportions of oxidizing radical activity to O2-detected in human neutrophils stimulated to a variety of agonists. The ethylene assay for oxidizing radical activity may detect different classes of oxidizing species capable of reacting with the aldehyde substrate. The complexity of defining the oxygen-derived radicals of the ethylene assay suggests methodologic difficulties of either quantitating or precisely defining the radicals generated in the respiratory burst by this method.

Heterogeneous Pathways of Oxidizing Radical Production in Human Neutrophils and the HL-60 Cell Line