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Suckling mice infected with reovirus type 3 were examined for changes in the epithelial brush border of the small intestine. After 3 days of infection with reovirus type 3, no significant changes were found in intestinal morphology or activity of any enzymes tested. After 6 days, villi were shortened and blunted with lymphangiectatic lesions and mild mononuclear infiltration in the lamina propria. In addition, there was a significant decrease in lactase (P &lt; 0.001) and enterokinase activity (P &lt; 0.05). However, there were no significant changes in the activities of alkaline phosphatase. In contrast, maltase (P &lt; 0.001) and leucine aminopeptidase (P &lt; 0.05) activities in the infected mice were significantly increased. These data suggest that brush border enzymes are affected differently by reovirus infection.

Small Intestinal Epithelial Brush Border Enzymatic Changes in Suckling Mice Infected with Reovirus Type 3