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Guanylate cyclase, cGMP phosphodiesterase and protein kinase activities were determined in kidneys of developing and adult rats. Guanylate cyclase activities of crude kidney homogenates, 100,000 x g supernatant and pellet of 7- and 21-day-old and adult rats were determined (Table I). In the kidneys of 7-day-old rats activity was 162% of adult controls in the homogenates (P less than .001), 144% in the soluble (P less than .005) and 308% in the particulate fraction (P less than .001). In 3-week-old rats activity was still significantly higher at 144% in the homogenate (P less than 0.02) and at 225% in the particulate (P less than .001). Phosphodiesterase activity for cGMP was 7488 +/- 831 pmol cGMP/mg protein . min in 1-week-old and 7674 +/- 1120 in 3-week-old rats vs. 4042 +/- 122 in the adults (P less than .025) (Table II). Chromatography on Sephadex G-200 showed two peaks of cGMP-stimulatable protein kinase in both the adult and newborn kidney and in addition a minor peak of cGMP-stimulatable kinase in the newborn kidny only (Fig. 2).

Increases of Guanosine 3′,5′-Monophosphate-related Enzymes in Kidneys of Developing Rats