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Corresponding author: Gottfried E. Konecny, MD, Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, 2825 Santa Monica Blvd, Ste 200, Santa Monica, CA 90404-2429; gkonecny@mednet.ucla.edu. AUTHOR CONTRIBUTIONS Conception and design: Maira P. Campos, Melissa Cohen, Dennis J. Slamon, Julia Elvin, Gottfried E. Konecny Provision of study materials or patients: Maira P. Campos, Melissa Cohen, Erika Von Euw, Gottfried E. Konecny Collection and assembly of data: Maira P. Campos, Melissa Cohen, Erika Von Euw, Victor Velculescu, Jennifer L. Kujak, Julia Elvin, Gottfried E. Konecny Data analysis and interpretation: Maira P. Campos, Erika Von Euw, Victor Velculescu, Dylan Conklin, Dorothy Hallberg, Julia Elvin, Gottfried E. Konecny Manuscript writing: All authors Final approval of manuscript: All authors Accountable for all aspects of the work: All authors Maira P. Campos No relationship to disclose Melissa Cohen No relationship to disclose Erika Von Euw No relationship to disclose Victor Velculescu Leadership: Personal Genome Diagnostics Stock and Other Ownership Interests: Personal Genome Diagnostics, Ignyta Consulting or Advisory Role: Quintiles, Janssen Diagnostics, Ignyta, Personal Genome Diagnostics Patents, Royalties, Other Intellectual Property: Receive royalties for discoveries our group has made at Johns Hopkins that have been licensed by Qiagen; receive royalties for discoveries our group has made at Johns Hopkins that have been licensed by Myriad; receive royalties for discoveries our group has made at Johns Hopkins that have been licensed by Personal Genome Diagnostics; receive royalties for discoveries our group has made at Johns Hopkins that have been licensed by Genzyme; receive royalties for discoveries our group has made at Johns Hopkins that have been licensed by Roche Jennifer L. Kujak Honoraria: Eli Lilly, Blue Earth Diagnostics Consulting or Advisory Role: Eli Lilly, Blue Earth Diagnostics Speakers’ Bureau: Eli Lilly, Blue Earth Diagnostics Dylan Conklin No relationship to disclose Dorothy Hallberg No relationship to disclose Dennis J. Slamon Leadership: Biomarin Stock and Other Ownership Interests: Pfizer Honoraria: Novartis Consulting or Advisory Role: Novartis, Eli Lilly Travel, Accommodations, Expenses: Pfizer, Biomarin, Novartis Julia Elvin Employment: Foundation Medicine Stock and Other Ownership Interests: Foundation Medicine Gottfried E. Konecny Stock and Other Ownership Interests: Foundation Medicine Speakers’ Bureau: Clovis Oncology, AstraZeneca, Tesaro Travel, Accommodations, Expenses: Novartis

BRAF Mutations Occur Infrequently in Ovarian Cancer but Suggest Responsiveness to BRAF and MEK Inhibition