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Aims and Method  A cross-sectional survey of patient drug prescriptions on two elderly psychiatric wards was carried out to estimate the potential of drug–drug interactions. Two standardised databases, British National Formulary (BNF; British Medical Association &amp; Royal Pharmaceutical Society of Great Britain, 2007) and Upto Date ( www.uptodate.com/ ), were employed.    Results  A majority (96%) of drug prescriptions in our study could potentially cause drug–drug interactions. Most patients were on multiple drugs (on average eight drugs per patient). There was poor concordance between the two databases: BNF picked up fewer cases of potential drug–drug interactions than Upto Date (43  v . 152 instances) and they also estimated the potential for hazardousness differently.    Clinical Implications  Polypharmacy is common in elderly psychiatric patients and this increases the possibility of a drug–drug interaction. Estimating the risk of interactions depends on a sound knowledge in therapeutics and/or referring to a standardised source of information. the results of this study question the concordance of two well-referenced databases.

Prescribing safely in elderly psychiatric wards: survey of possible drug interactions