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Background Vulvovaginal candidiasis is a widespread mycotic infection that affects a large proportion of women of childbearing age. Its management in traditional medicine is based on the use of medicinal plants. This study aimed to evaluate the antifungal activity of  Ocimum gratissimum  L . ,  Lantana camara  L. and  Pteleopsis suberosa  Engl. &amp; Diels used in the treatment of vulvovaginal candidiasis in Benin. Results The data obtained from the in vitro antifungal test show that the strains tested (ATCC 90028 and two clinical strains: 1MA and 3MA) were more sensitive to aqueous extracts with a better effect for  Pteleopsis suberosa . This potential of the tested extracts correlated with their richness in total polyphenols. The extract of the  Pteleopsis suberosa  was very active on the inhibition of the reference strain ATCC 90028. On the clinical strains (1MA and 3MA) the aqueous extract of  Pteleopsis suberosa  showed a better MIC on the 1MA strain. In vivo model, inoculation of 100 µL of the concentrated  Candida albicans  suspension 1.5 × 10 5  UFC/mL induced the candidiasis of the female Wistar rat. The treatment with the aqueous extract of  Pteleopsis suberosa , like fluconazole (reference drug), significantly reduced  Candida albicans  infection at a dose of 100 mg/kg after 1, 7 and 13 days of treatment. Conclusion This study revealed the potential antifungal of the  Ocimum gratissimum ,  Lantana camara  and  Pteleopsis suberosa .  Pteleopsis suberosa  has better antifungal activity in vitro and in vivo. These observations justify the use of their medicinal plant in the traditional treatment of vulvovaginal candidiasis in Benin.

future journal of pharmaceutical sciences

Antifungal activity of Ocimum gratissimum L., Lantana camara L. &amp; Pteleopsis suberosa Engl. &amp; Dies used in the treatment of vulvovaginal candidiasis in Benin