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The pharmaceutical industry and the National Regulatory Authorities are now focusing on the quantification of multi-component drugs for quality control testing. Recently, the utilization of the ultraviolet spectrophotometric methods has become vital for the analytical studies for the routine analysis of different fixed-dose combination products either in the presence of a minor component in their combination or not. This article reviewed several published methods to those that have been applied to quantify some pharmaceutical combinations containing minor components through the last two decades. The applied spectrophotometric methods are labor, time-saving, and also considered a cheap substitute for the overpriced high-performance liquid chromatographic technique.

future journal of pharmaceutical sciences

Ultraviolet spectrophotometric methods for the determination of the minor component presented in fixed-dose pharmaceutical combinations through the last two decades (2000–2020)