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Background Years ago the utility of of 18 F-fluorodeoxyglucose-positron emission tomography/computerized tomography ( 18 FDG-PET/CT) in differentiated thyroid cancer was confined mainly to cases with elevated serum thyroglobulin and negative  131 I whole body scan. In this study, we try to assess the diagnostic performance of  18 FDG-PET/CT in recurrent differentiated thyroid cancer patients with positive  131 I whole body scan and in addition to evaluate the impact of  18 FDG-PET/CT on the treatment strategy. Results The  18 FDG PET/CT detected tumor recurrence in 35 (81.3%) patients most of them (91.4%) were in stage IV, while the rest 8.5% was in stage III. No recurrence was detected among patients in stage II and III by  18 FDG PET/CT. Regarding lesion-based analysis, sensitivity of  18 FDG-PET/CT was superior to that of  131 I post-therapeutic whole body scan (TxWBS) (78.2% vs. 69.4%, respectively), while both modalities had the same specificity (50%).  18 FDG-PET/CT changed the treatment plan in 18 (41.6%) patients. Conclusion 18 FDG-PET/CT may be complementary to  131 ITxWBS in high-risk DTC with impact on treatment strategy.

the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine

Additive value of 18FDG-PET/CT to positive 131I whole body scan in recurrent differentiated thyroid cancer patients with potential influence on treatment strategy: single Egyptian center experience