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BackgroundThe aim of the study is to evaluate the role and efficacy of transvaginal ultrasound in detection of endometrial changes in breast cancer patients under hormonal therapy in correlation with histopathological results of endometrial biopsies. Fifty patients with breast cancer under tamoxifen were subjected to transvaginal ultrasonography, and the results are compared with histopathological results of endometrial biopsies from March 2018 to November 2018.ResultsTwenty-two patients (44%) had normal regular endometrium, and twenty-eight patients (56%) had abnormal ultrasonographic appearance with different types of pathology; there were 24 patients (85.7%) with endometrial abnormality and 4 patients (14.3%) with adnexal pathology. The twenty-four patients with endometrial abnormality were as follows: 10% endometrial atrophy, 4% endometrial carcinoma, 14% endometrial hyperplasia, and 7% endometrial polyp with sensitivity of 92.9% and accuracy of 96% in comparison to histopathology results.ConclusionWe found in our study that transvaginal ultrasonography is a sensitive and rather specific method to evaluate the endometrial lesions, so we concluded that it is a necessary screening tool for detection of endometrial abnormalities in breast cancer patients under hormonal therapy.

Role of transvaginal ultrasound in detection of endometrial changes in breast cancer patients under hormonal therapy