English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background Multiple sclerosis (MS) is a chronic inflammatory disease. Various long non-coding RNAs (lncRNAs) appear to have an important role in the pathophysiology of MS. This study aimed at evaluating the expression levels of lncRNAs,  MIAT ,  H19,  and  NRON  in peripheral blood of MS cases to a healthy control group. We collected blood samples of 95 MS cases (76 relapsing–remitting (RR) and 19 secondary progressive (SP) MS) and 95 controls. We used quantitative real-time PCR for the evaluation of gene expression. The correlation between expression with clinical parameters was analyzed by a multiple linear regression model. Receiver operating characteristic (ROC) curve analysis was carried out to detect the diagnostic potential of lncRNAs levels according to the area under the curve (AUC). Results MIAT, H19 , and  NRON  were significantly increased in the RRMS and SPMS subgroups compared to the controls. We found that the  H19  and  MIAT  expression significantly were higher in SPMS compared with RRMS. Patients with RRMS had a greater level of the average  NRON  expression is compared with SPMS patients. The expression level of  H19  significantly was higher in females relative to male patients. Based on the area under curve (AUC) values,  NRON  had the best performance in the differentiation of MS patients from controls (AUC = 0.95,  P  &lt; 0.0001). A combination of  MIAT ,  H19 , and  NRON  expression levels could be useful in differentiating MS patients with 93.6% sensitivity, 98.9% specificity, and diagnostic power of 0.96 ( P  &lt; 0.0001). Conclusions The levels of  MIAT ,  H19 , and  NRON  in peripheral blood could be important biomarkers for MS diagnosis.

Expression and diagnostic values of MIAT, H19, and NRON long non-coding RNAs in multiple sclerosis patients