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The effect of standard therapeutic strategies on  Helicobacter pylori  infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of  L. paracasei  HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with  Perilla frutescens  var. acuta ( P. frutescens )and  Glycyrrhiza glabra  ( G. glabra ) extracts.   P. frutescens  extract and  G. glabra  extract were found to inhibit the growth of  H. pylori  in a concentration-dependent manner, and the combination of  L. paracasei  HP7 and  P. frutescens  extract and  G. glabra  extract effectively inhibited  H. pylori  from attaching to AGS a gastric epithelial cells. Moreover,  L. paracasei  HP7 complex mixture containing  P. frutescens  and  G. glabra  extracts has been shown to inhibit  H. pylori  virulence genes such as AlpA, CagA, FlaA and UreA. When  H. pylori -infected mice were administered a complex mixture of  L. paracasei  HP7 containing  P. frutescens  and  G. glabra  extract, the infection rate of  H. pylori  was significantly reduced. In addition, the  L. paracasei  HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in  H. pylori  infected mice.  These results suggest that a complex mixture of  L. paracasei  HP7 containing  P. frutescens  and  G. glabra  extracts may be an alternative to treating diseases caused by  H. pylori  infection.

laboratory animal research

Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra