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Background Malaria is still a vital global health issue. The greatest disease burden is in sub-Saharan Africa. A. aspera is one of the medicinal herbs commonly used traditionally. The continuous resistance of Plasmodium falciparum , to available anti-malarial agents has led to the search for an alternative substance to combat malaria; hence, the study aimed to establish the potential of the extract from the shoot of Achyranthes aspera as an alternative anti-malarial agent against Plasmodium berghei (NK-65) strain in mice model. Acute toxicity test was performed as per the Organization for Economic Cooperative Development guidelines, 425. Rodent malaria parasite P. berghei at 1 × 10 7 parastemia was inoculated into Swiss albino mice of both sexes intraperitoneally. The extract was administered through oral route by an intra-gastric tube once daily for 5 days according to the Rane’s curative test. Chloroquine and Artemisinin were used as standard drugs and were administered through the same route. Results Phytochemical screening of A. aspera revealed the presence of phenols, tannins, alkaloids, saponins, flavonoids, and balsam. A. aspera extract neither caused any sign of gross toxicity nor caused mortality in the mice up to a single dose of 5000 mg/kg/bwt. The aqueous extract, of A. aspera , showed significant reduction ( p < 0.05) in parasitemia at dose 400 mg/kg/day and 600 mg/kg/day in Swiss albino mice compared to negative control. The treated mice had prolonged survival time at all doses. Extracts prevented P. berghei induced body weight loss and temperature reduction compared to the negative control. Conclusion We conclude that the shoot extract of A. aspera is safe and displayed promising anti-malarial activity. This may account for its traditional use for malaria treatment among some locals in Nigeria.

Evaluation of Achyranthes aspera shoot extract as an alternative therapy for malaria