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Background  To determine the utility of single-contrast-bolus hepatic extracellular volume (ECV) fraction measurement at different time points to detect and quantify hepatic fibrosis.    Methods  Different grades of liver fibrosis were induced in 23 male Sprague-Dawley rats by carbon-tetrachloride (CCl 4 ) intoxication. In ten control rats, no fibrosis was induced. Native T1 values and ECV fraction were assessed by using quantitative magnetic resonance imaging (MRI) mapping; only one contrast bolus was applied (gadobutrol 0.1 mmol/kg). ECV values were determined 5, 15, and 25 min after injection. Hepatic fibrosis was quantified histologically by Sirius red staining.    Results  For the 8-week-CCl 4  group, the ECV fraction values obtained 5 (23.5 ± 4.8%, mean ± standard deviation), 15 (23.6 ± 4.8%), and 25 min (23.7 ± 4.7%) after injection were constant over time ( p  = 0.998); constant data 5–25 min after injection were also observed for the 16-week-CCl 4  group and controls. Liver ECV after 15 min significantly increased with the severity of fibrosis: 18.0 ± 3.0% (controls)  versus  23.6 ± 4.8% (8-week-CCl4)  versus  30.5 ± 3.3% (16-week-CCl4) ( p  <  0.001). ECV values after 5, 15, and 25 min significantly correlated with Sirius red staining ( p  <  0.001 for all parameters).    Conclusions  Hepatic ECV obtained using a single-contrast-bolus technique can be measured 5, 15, and 25 min after injection, obtaining constant values over time, each of them being suitable to detect diffuse hepatic fibrosis. In clinical practice, post-contrast T1 relaxation times for liver ECV fraction determination might be obtained at only one time point.

Quantification of liver fibrosis: extracellular volume fraction using an MRI bolus-only technique in a rat animal model