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Hair loss, known as alopecia, causes psychological stress and influences social interactions. At present, treatment for hair loss is somewhat limited, transient, and unpredictable. Based on the critical role of sonic hedgehog (Shh) in hair follicle development, Shh itself would be a good therapeutic candidate for the prevention of hair loss as well as promotion of hair growth.

Hair growth-promoting effect of recombinant human sonic hedgehog proteins