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3D printing technology has allowed the creation of custom applicators for high dose rate (HDR) brachytherapy, especially for complex anatomy. With conformal therapy comes the need for advanced dosimetric verification. It is important to demonstrate how dose to 3D printed materials can be related to dose to water. This study aimed to determine dose differences and uncertainties using 3D printed PLA and ABS plastics for Radiochromic film calibration in HDR brachytherapy.  Gafchromic EBT3 film pieces were irradiated in water with an Ir-192 source at calculated dose levels ranging from 0 to 800 cGy, to create the control calibration curve. Similarly, film was placed below 3D printed PLA and ABS blocks and irradiated at the same dose levels calculated for water, ranging from 0 to 800 cGy. After a 72-h development time, film pieces were scanned on a flatbed scanner and the median pixel value was recorded in the region of highest dose. This value was converted to net optical density (NOD). A rational function was used to fit a calibration curve in water that relates NOD to dose for red, green, and blue color channels. Based on this fitted curve, ABS and PLA NOD values were used to estimate dose in 3D printed plastics.  From the fitted calibration curve, mean residual error between measured and planned dose to water was less than 1% for each color channel at high dose levels. At high dose levels, ABS and PLA mean residual errors were about 6.9 and 7.8% in the red channel, while 5.2 and 5.7% in the green channel. Combined uncertainties measured to be about 6.9% at high dose levels. This study demonstrated dose differences and uncertainties using 3D printed applicators for HDR Ir-192 brachytherapy.

Dose calibration of Gafchromic EBT3 film for Ir-192 brachytherapy source using 3D-printed PLA and ABS plastics